Weight and length are two factors - the real 'concern' would be having a human trying to lift, maneuver, and insert that heavier shell into the breech while the vehicle is moving.
An artillery piece is sitting static when firing - the troops are lifting a heavy shell, but do not have to deal with the additional factor of being on a moving platform and having extra G-loading impacting them as they try to maneuver the round. A tanker has to be able to pull the round out of the ready-use location, probably spin it around, then slam it into the breech, while the tank is driving, going up or down hill, slamming around.
Having a much longer, heavier round in their hands while dealing with the pitching/rolling/yawing movement of the tank is the real hazard.
I suspect that a 120mm is close to the limit of what a person can manage in that kind of environment.